Reference - Detail
| RRC ID | 71022 |
|---|---|
| Author | Lopez JAV, Nogawa T, Yoshida K, Futamura Y, Osada H. |
| Title | 2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture. |
| Journal | Biosci Biotechnol Biochem |
| Abstract |
2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth of Streptomyces sp. 80H647 along with 2 known purine derivatives, 5'-methylthioinosine (2) and AT-265 (dealanylascamycin, 3). The structure elucidation of compound 1 was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth of Plasmodium falciparum 3D7 with a GI50 of 2.4 µm and had no effect on the growth of Arabidopsis at 2 µm. This is the first report of an N7-methylated zeatin-type natural product from Streptomyces and as an antimalarial compound. |
| Volume | 86(1) |
| Pages | 31-36 |
| Published | 2021-12-22 |
| DOI | 10.1093/bbb/zbab192 |
| PII | 6420239 |
| PMID | 34734225 |
| MeSH | Antimalarials* / chemistry Antimalarials* / isolation & purification Antimalarials* / pharmacology Arabidopsis / drug effects Biological Products / chemistry Biological Products / isolation & purification Biological Products / pharmacology Plasmodium falciparum* / drug effects Plasmodium falciparum* / growth & development Streptomyces* / chemistry Streptomyces* / metabolism |
| Resource | |
| General Microbes | JCM9888 |