Reference - Detail
| RRC ID | 71040 |
|---|---|
| Author | Yoshida K, Hirano R, Sakai Y, Choi M, Sakanaka M, Kurihara S, Iino H, Xiao JZ, Katayama T, Odamaki T. |
| Title | Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter. |
| Journal | Commun Biol |
| Abstract |
This study aims to understand the mechanistic basis underlying the response of Bifidobacterium to lactulose ingestion in guts of healthy Japanese subjects, with specific focus on a lactulose transporter. An in vitro assay using mutant strains of Bifidobacterium longum subsp. longum 105-A shows that a solute-binding protein with locus tag number BL105A_0502 (termed LT-SBP) is primarily involved in lactulose uptake. By quantifying faecal abundance of LT-SBP orthologues, which is defined by phylogenetic analysis, we find that subjects with 107 to 109 copies of the genes per gram of faeces before lactulose ingestion show a marked increase in Bifidobacterium after ingestion, suggesting the presence of thresholds between responders and non-responders to lactulose. These results help predict the prebiotics-responder and non-responder status and provide an insight into clinical interventions that test the efficacy of prebiotics. |
| Volume | 4(1) |
| Pages | 541 |
| Published | 2021-5-10 |
| DOI | 10.1038/s42003-021-02072-7 |
| PII | 10.1038/s42003-021-02072-7 |
| PMID | 33972677 |
| PMC | PMC8110962 |
| MeSH | ATP-Binding Cassette Transporters / metabolism* Adolescent Adult Aged Aged, 80 and over Bacterial Proteins / metabolism* Bifidobacterium / drug effects Bifidobacterium / growth & development* Bifidobacterium / metabolism Cross-Sectional Studies Feces / microbiology* Female Gastrointestinal Agents / administration & dosage Gastrointestinal Microbiome / drug effects* Gastrointestinal Tract / drug effects Gastrointestinal Tract / microbiology* Humans Lactulose / administration & dosage* Middle Aged Young Adult |
| Altmetric score |
オルトメトリクス指標項目
|
| The most frequently cited source | X(Twitter) |
| Total number of mentions | 6 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM1222 JCM12489 JCM1200 JCM1194 JCM1217 JCM1192 JCM15439 JCM7096 JCM1255 JCM8224 |