| RRC ID |
71096
|
| Author |
Hsu CC, Okumura R, Motooka D, Sasaki R, Nakamura S, Iida T, Takeda K.
|
| Title |
Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease.
|
| Journal |
Int Immunol
|
| Abstract |
Dysfunction of the intestinal mucosal barrier causes inflammatory bowel diseases (IBDs). Indeed, mucosal barrier impairment in the gut of IBD patients results from decreased expression of barrier molecules. Ly6/Plaur domain containing 8 (Lypd8) segregates microbiota from the colonic epithelial layer. In this study, we found that Lypd8-/- mice, in which flagellated bacteria invaded the mucosal surface of the colon, developed spontaneous colitis when dysbiosis was induced by a high-fat diet (HFD). On the basis of this finding, we assessed whether the application of human LYPD8 (hLYPD8) protein exhibiting the glycan-dependent inhibition of bacterial motility is effective in a colitis model. Oral and anal treatments with hLYPD8 protein ameliorate dextran sulfate sodium-induced colitis and HFD-induced colitis in Lypd8-/- mice. These results indicate a therapeutic potential of hLYPD8 protein supplementation for IBD.
|
| Volume |
33(7)
|
| Pages |
359-372
|
| Published |
2021-6-18
|
| DOI |
10.1093/intimm/dxab012
|
| PII |
6211059
|
| PMID |
33822948
|
| MeSH |
Animals
Colitis / chemically induced
Colitis / metabolism
Colon / metabolism*
Dextran Sulfate / pharmacology
Diet, High-Fat
Disease Models, Animal
Dysbiosis / chemically induced
Dysbiosis / metabolism
Female
GPI-Linked Proteins / metabolism*
Gastrointestinal Microbiome / physiology
Humans
Inflammation / chemically induced
Inflammation / metabolism*
Inflammatory Bowel Diseases / chemically induced
Inflammatory Bowel Diseases / metabolism*
Intestinal Mucosa / metabolism
Mice
Mice, Inbred C57BL
|
| Resource |
| General Microbes |
JCM1649 |
