Reference - Detail
| RRC ID | 71096 |
|---|---|
| Author | Hsu CC, Okumura R, Motooka D, Sasaki R, Nakamura S, Iida T, Takeda K. |
| Title | Alleviation of colonic inflammation by Lypd8 in a mouse model of inflammatory bowel disease. |
| Journal | Int Immunol |
| Abstract |
Dysfunction of the intestinal mucosal barrier causes inflammatory bowel diseases (IBDs). Indeed, mucosal barrier impairment in the gut of IBD patients results from decreased expression of barrier molecules. Ly6/Plaur domain containing 8 (Lypd8) segregates microbiota from the colonic epithelial layer. In this study, we found that Lypd8-/- mice, in which flagellated bacteria invaded the mucosal surface of the colon, developed spontaneous colitis when dysbiosis was induced by a high-fat diet (HFD). On the basis of this finding, we assessed whether the application of human LYPD8 (hLYPD8) protein exhibiting the glycan-dependent inhibition of bacterial motility is effective in a colitis model. Oral and anal treatments with hLYPD8 protein ameliorate dextran sulfate sodium-induced colitis and HFD-induced colitis in Lypd8-/- mice. These results indicate a therapeutic potential of hLYPD8 protein supplementation for IBD. |
| Volume | 33(7) |
| Pages | 359-372 |
| Published | 2021-6-18 |
| DOI | 10.1093/intimm/dxab012 |
| PII | 6211059 |
| PMID | 33822948 |
| MeSH | Animals Colitis / chemically induced Colitis / metabolism Colon / metabolism* Dextran Sulfate / pharmacology Diet, High-Fat Disease Models, Animal Dysbiosis / chemically induced Dysbiosis / metabolism Female GPI-Linked Proteins / metabolism* Gastrointestinal Microbiome / physiology Humans Inflammation / chemically induced Inflammation / metabolism* Inflammatory Bowel Diseases / chemically induced Inflammatory Bowel Diseases / metabolism* Intestinal Mucosa / metabolism Mice Mice, Inbred C57BL |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 4 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| General Microbes | JCM1649 |