| RRC ID |
71292
|
| 著者 |
Hashizume H, Harada S, Sawa R, Iijima K, Kubota Y, Shibuya Y, Nagasaka R, Hatano M, Igarashi M.
|
| タイトル |
New chloptosins B and C from an Embleya strain exhibit synergistic activity against methicillin-resistant Staphylococcus aureus when combined with co-producing compound L-156,602.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
Two new dimeric cyclohexapeptides, chloptosins B and C, were discovered from the culture broth of Embleya sp. MM621-AF10 together with the known compounds chloptosin and L-156,602. The structures of the new chloptosins were determined by spectroscopic studies and advanced Marfey's methods. The stereo structure of the constituent isoleucine was determined by C3 Marfey's analysis. Chloptosins demonstrated potent antimicrobial activity against Gram-positive bacteria including drug-resistant strains of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci with MICs of 0.5-2 µg ml-1. The antimicrobial activities of chloptosins were enhanced by addition of co-producing compound L-156,602, as shown by checkerboard analysis.
|
| 巻・号 |
74(1)
|
| ページ |
80-85
|
| 公開日 |
2021-1-1
|
| DOI |
10.1038/s41429-020-0361-y
|
| PII |
10.1038/s41429-020-0361-y
|
| PMID |
32796954
|
| MeSH |
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Methicillin-Resistant Staphylococcus aureus / drug effects*
Molecular Structure
Peptides, Cyclic / administration & dosage
Peptides, Cyclic / chemistry
Peptides, Cyclic / pharmacology
Pyridazines / chemistry
Pyridazines / pharmacology
|
| リソース情報 |
| 一般微生物 |
JCM5803
JCM5804 |
