論文 - 詳細
| RRC ID | 71302 |
|---|---|
| 著者 | Watanabe J, Hashimoto N, Yin T, Sandagdorj B, Arakawa C, Inoue T, Suzuki S. |
| タイトル | Heat-killed Lactobacillus brevis KB290 attenuates visceral fat accumulation induced by high-fat diet in mice. |
| ジャーナル | J Appl Microbiol |
| Abstract |
AIMS:This study aimed to evaluate the anti-adiposity effect of heat-killed Lactobacillus brevis KB290 originating from traditional Japanese fermented pickles in mice fed a high-fat diet (HFD). METHODS AND RESULTS:C57BL/6J mice were fed a normal-fat diet, HFD or HFD supplemented with heat-killed KB290 for 8 weeks. Epididymal and renal adipose tissue weights, as well as areas of epididymal adipocytes, were significantly lower in the mice fed a HFD supplemented with KB290 than in those fed an unsupplemented HFD. Mice whose diets were supplemented with KB290 had elevated adiponectin and β3-adrenergic receptor expression in epididymal adipose tissue and an accompanying higher serum free fatty acid level. Furthermore, the HFD-induced elevations in serum glucose, insulin and HOMA-IR were significantly suppressed by dietary supplementation with KB290. Amplicon sequencing of 16S rRNA genes revealed that KB290 ingestion altered the composition of the intestinal microbiota. CONCLUSIONS:Heat-killed L. brevis KB290 suppressed diet-induced visceral fat accumulation and ameliorated diet-induced metabolic symptoms and intestinal gut microbiota modifications, suggesting possibility of novel paraprobiotic. SIGNIFICANCE AND IMPACT OF THE STUDY:Heat-killed L. brevis KB290 is useable as a material to develop functional foods that attenuate visceral fat accumulation. |
| 巻・号 | 131(4) |
| ページ | 1998-2009 |
| 公開日 | 2021-10-1 |
| DOI | 10.1111/jam.15079 |
| PMID | 33742756 |
| PMC | PMC8518035 |
| MeSH | Animals Diet, High-Fat* / adverse effects Hot Temperature Intra-Abdominal Fat Levilactobacillus brevis* / genetics Mice Mice, Inbred C57BL RNA, Ribosomal, 16S |
| リソース情報 | |
| 一般微生物 | JCM17312 |