Reference - Detail
| RRC ID | 71367 |
|---|---|
| Author | Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, Sato S, Yoshida Y, Tsuji S, Uemura K, Wakita M, Matsudaira T, Matsumoto T, Kawamoto S, Takahashi A, Itatani Y, Miki H, Takamatsu M, Obama K, Takeuchi K, Suematsu M, Ohtani N, Fukunaga Y, Ueno M, Sakai Y, Nagayama S, Hara E. |
| Title | Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion. |
| Journal | Nat Commun |
| Abstract |
Emerging evidence is revealing that alterations in gut microbiota are associated with colorectal cancer (CRC). However, very little is currently known about whether and how gut microbiota alterations are causally associated with CRC development. Here we show that 12 faecal bacterial taxa are enriched in CRC patients in two independent cohort studies. Among them, 2 Porphyromonas species are capable of inducing cellular senescence, an oncogenic stress response, through the secretion of the bacterial metabolite, butyrate. Notably, the invasion of these bacteria is observed in the CRC tissues, coinciding with the elevation of butyrate levels and signs of senescence-associated inflammatory phenotypes. Moreover, although the administration of these bacteria into ApcΔ14/+ mice accelerate the onset of colorectal tumours, this is not the case when bacterial butyrate-synthesis genes are disrupted. These results suggest a causal relationship between Porphyromonas species overgrowth and colorectal tumourigenesis which may be due to butyrate-induced senescence. |
| Volume | 12(1) |
| Pages | 5674 |
| Published | 2021-9-28 |
| DOI | 10.1038/s41467-021-25965-x |
| PII | 10.1038/s41467-021-25965-x |
| PMID | 34584098 |
| PMC | PMC8479117 |
| MeSH | Bacteria / classification Bacteria / genetics Bacteria / metabolism* Butyrates / metabolism* Carcinogenesis / pathology* Cellular Senescence / physiology Colorectal Neoplasms / microbiology Colorectal Neoplasms / pathology* Epithelial Cells / microbiology Epithelial Cells / physiology Feces / microbiology Gastrointestinal Microbiome* Humans Intestines / cytology Intestines / microbiology Intestines / physiology Porphyromonas / genetics Porphyromonas / metabolism RNA, Ribosomal, 16S / genetics |
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 140 |
| Altmetric score changes over past 6months | 0.5 |
| Resource | |
| General Microbes | JCM16135 JCM10004 JCM8532 JCM12970 JCM1769 JCM15636 JCM6323 JCM8525 JCM11150 JCM10645 |