論文 - 詳細
| RRC ID | 71374 |
|---|---|
| 著者 | Hattori K, Akiyama M, Seki N, Yakabe K, Hase K, Kim YG. |
| タイトル | Gut Microbiota Prevents Sugar Alcohol-Induced Diarrhea. |
| ジャーナル | Nutrients |
| Abstract |
While poorly-absorbed sugar alcohols such as sorbitol are widely used as sweeteners, they may induce diarrhea in some individuals. However, the factors which determine an individual's susceptibility to sugar alcohol-induced diarrhea remain unknown. Here, we show that specific gut bacteria are involved in the suppression of sorbitol-induced diarrhea. Based on 16S rDNA analysis, the abundance of Enterobacteriaceae bacteria increased in response to sorbitol consumption. We found that Escherichia coli of the family Enterobacteriaceae degraded sorbitol and suppressed sorbitol-induced diarrhea. Finally, we showed that the metabolism of sorbitol by the E. coli sugar phosphotransferase system helped suppress sorbitol-induced diarrhea. Therefore, gut microbiota prevented sugar alcohol-induced diarrhea by degrading sorbitol in the gut. The identification of the gut bacteria which respond to and degrade sugar alcohols in the intestine has implications for microbiome science, processed food science, and public health. |
| 巻・号 | 13(6) |
| 公開日 | 2021-6-12 |
| DOI | 10.3390/nu13062029 |
| PII | nu13062029 |
| PMID | 34204751 |
| PMC | PMC8231616 |
| MeSH | Animals Diarrhea / chemically induced* Diarrhea / prevention & control Escherichia coli / metabolism* Gastrointestinal Microbiome / physiology* Male Mice Mice, Inbred C57BL RNA, Ribosomal, 16S Sorbitol / adverse effects* Sugar Alcohols / adverse effects* |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | News |
| 各媒体での言及数の合計 | 48 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 8.0 |
| リソース情報 | |
| 一般微生物 | JCM1297 JCM14986 JCM1429 JCM12243 JCM15734 JCM15735 |