| RRC ID |
71472
|
| 著者 |
Oguchi M, Tanaka S, Pan X, Kikusui T, Moriya-Ito K, Kato S, Kobayashi K, Sakagami M.
|
| タイトル |
Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain.
|
| ジャーナル |
Commun Biol
|
| Abstract |
The lateral prefrontal cortex (LPFC) has a strong monosynaptic connection with the caudate nucleus (CdN) of the striatum. Previous human MRI studies have suggested that this LPFC-CdN pathway plays an important role in inhibitory control and working memory. We aimed to validate the function of this pathway at a causal level by pathway-selective manipulation of neural activity in non-human primates. To this end, we trained macaque monkeys on a delayed oculomotor response task with reward asymmetry and expressed an inhibitory type of chemogenetic receptors selectively to LPFC neurons that project to the CdN. Ligand administration reduced the inhibitory control of impulsive behavior, as well as the task-related neuronal responses observed in the local field potentials from the LPFC and CdN. These results show that we successfully suppressed pathway-selective neural activity in the macaque brain, and the resulting behavioral changes suggest that the LPFC-CdN pathway is involved in inhibitory control.
|
| 巻・号 |
4(1)
|
| ページ |
1088
|
| 公開日 |
2021-9-16
|
| DOI |
10.1038/s42003-021-02623-y
|
| PII |
10.1038/s42003-021-02623-y
|
| PMID |
34531520
|
| PMC |
PMC8446038
|
| MeSH |
Animals
Clozapine / analogs & derivatives*
Clozapine / pharmacology
Corpus Striatum / drug effects*
Corpus Striatum / metabolism
Eye Movements / drug effects
Eye Movements / physiology
Genetic Vectors
Macaca fuscata / physiology
Male
Memory, Short-Term / drug effects
Memory, Short-Term / physiology*
Neurons / drug effects*
Neurons / metabolism
Prefrontal Cortex / drug effects*
Prefrontal Cortex / metabolism
Reaction Time / drug effects
Receptors, G-Protein-Coupled / genetics*
Receptors, G-Protein-Coupled / metabolism
Reward
Synaptic Transmission / drug effects*
Transduction, Genetic
|
| IF |
4.165
|
| リソース情報 |
| ニホンザル |
|
