論文 - 詳細
| RRC ID | 71493 |
|---|---|
| 著者 | Hasegawa T, Chiken S, Kobayashi K, Nambu A. |
| タイトル | Subthalamic nucleus stabilizes movements by reducing neural spike variability in monkey basal ganglia. |
| ジャーナル | Nat Commun |
| Abstract |
The subthalamic nucleus projects to the external and internal pallidum, the modulatory and output nuclei of the basal ganglia, respectively, and plays an indispensable role in controlling voluntary movements. However, the precise mechanism by which the subthalamic nucleus controls pallidal activity and movements remains elusive. Here, we utilize chemogenetics to reversibly reduce neural activity of the motor subregion of the subthalamic nucleus in three macaque monkeys (Macaca fuscata, both sexes) during a reaching task. Systemic administration of chemogenetic ligands prolongs movement time and increases spike train variability in the pallidum, but only slightly affects firing rate modulations. Across-trial analyses reveal that the irregular discharges in the pallidum coincides with prolonged movement time. Reduction of subthalamic activity also induces excessive abnormal movements in the contralateral forelimb, which are preceded by subthalamic and pallidal phasic activity changes. Our results suggest that the subthalamic nucleus stabilizes pallidal spike trains and achieves stable movements. |
| 巻・号 | 13(1) |
| ページ | 2233 |
| 公開日 | 2022-4-25 |
| DOI | 10.1038/s41467-022-29750-2 |
| PII | 10.1038/s41467-022-29750-2 |
| PMID | 35468893 |
| PMC | PMC9038919 |
| MeSH | Animals Basal Ganglia Globus Pallidus Haplorhini Movement Subthalamic Nucleus* |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ニホンザル | |