RRC ID 71552
Author Meparambu Prabhakaran D, Patel HR, Sivakumar Krishnankutty Chandrika S, Thomas S.
Title Genomic attributes differ between Vibrio parahaemolyticus environmental and clinical isolates including pathotypes.
Journal Environ Microbiol Rep
Abstract Vibrio parahaemolyticus is a marine bacterium and causes opportunistic gastroenteritis in humans. Clinical strains of V. parahaemolyticus contain haemolysin and type III secretion systems (T3SS) that define their pathotype. A growing number of strains isolated recently from the environment have acquired these virulence genes constituting a pool of potential pathogens. This study used comparative genomics to identify genetic factors that delineate environmental and clinical V. parahaemolyticus population and understand the similarities and differences between the T3SS2 phylotypes. The comparative analysis revealed the presence of a cluster of genes belonging to bacterial cellulose synthesis (bcs) in isolates of environmental origin. This cluster, previously unreported in V. parahaemolyticus, exhibit significant similarity to that of Aliivibrio fischeri, and might dictate a potentially new mechanism of its environmental adaptation and persistence. The study also identified many genes predicted in silico to be T3SS effectors that are unique to T3SS2β of tdh- trh+ and tdh+ trh+ pathotype and having no identifiable homologue in tdh+ trh- T3SS2α. Overall, these findings highlight the importance of understanding the genes and strategies V. parahaemolyticus utilize for the myriad interactions with its hosts, either marine invertebrates or humans.
Volume 14(3)
Pages 365-375
Published 2022-6-1
DOI 10.1111/1758-2229.13000
PMID 34461673
MeSH Bacterial Proteins / genetics Genomics Hemolysin Proteins / genetics Humans Vibrio parahaemolyticus* / genetics Virulence Virulence Factors / genetics
IF 2.975
Pathogenic bacteria V. parahaemolyticus RIMD2210633,