論文 - 詳細
| RRC ID | 71622 |
|---|---|
| 著者 | Zhou Y, Takano T, Li X, Wang Y, Wang R, Zhu Z, Tanokura M, Miyakawa T, Hachimura S. |
| タイトル | β-elemene regulates M1-M2 macrophage balance through the ERK/JNK/P38 MAPK signaling pathway. |
| ジャーナル | Commun Biol |
| Abstract |
Macrophages are classified into classically activated M1 macrophages and alternatively activated M2 macrophages, and the two phenotypes of macrophages are present during the development of various chronic diseases, including obesity-induced inflammation. In the present study, β-elemene, which is contained in various plant substances, is predicted to treat high-fat diet (HFD)-induced macrophage dysfunction based on the Gene Expression Omnibus (GEO) database and experimental validation. β-elemene impacts the imbalance of M1-M2 macrophages by regulating pro-inflammatory cytokines in mouse white adipose tissue both in vitro and in vivo. In addition, the RAW 264 cell line, which are macrophages from mouse ascites, is used to identify the effects of β-elemene on inhibiting bacterial endotoxin lipopolysaccharide (LPS)-induced phosphorylation of mitogen-activated protein kinase (MAPK) pathways. These pathways both induce and are activated by pro-inflammatory cytokines, and they also participate in the process of obesity-induced inflammation. The results highlight that β-elemene may represent a possible macrophage-mediated therapeutic medicine. |
| 巻・号 | 5(1) |
| ページ | 519 |
| 公開日 | 2022-5-31 |
| DOI | 10.1038/s42003-022-03369-x |
| PII | 10.1038/s42003-022-03369-x |
| PMID | 35641589 |
| PMC | PMC9156783 |
| MeSH | Animals Cytokines / metabolism Inflammation / drug therapy Inflammation / metabolism MAP Kinase Signaling System Macrophages* / metabolism Mice Obesity / drug therapy Obesity / etiology Obesity / metabolism Sesquiterpenes p38 Mitogen-Activated Protein Kinases* / metabolism |
| IF | 4.165 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |