RRC ID 71634
著者 Li F, Awale S, Tezuka Y, Kadota S.
タイトル Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines.
ジャーナル Nat Prod Commun
Abstract The cytotoxicity of 39 compounds, including eighteen flavonoids (flavanones, 1-10; flavones, 11-17; flavanol, 18), sixteen phenolic acid derivatives (aromatic acids, 19-24; aldehyde, 25; esters, 26-34) and five glycerides (35-39), isolated from Mexican propolis, were evaluated against a panel of six different cancer cell lines; murine colon 26-L5 carcinoma, murine B16-BL6 melanoma, murine Lewis lung carcinoma, human lung A549 adenocarcinoma, human cervix HeLa adenocarcinoma and human HT-1080 fibrosarcoma. A phenylpropanoid-substituted flavanol, (2R,3S)-8-[4-phenylprop-2-en-1-one]-4',7-dihydroxy-3',5-dimethoxyflavan-3-ol (18), showed the most potent cytotoxicity against A549 cells (IC50, 6.2 microM) and HT-1080 cells (IC50, 3.9 microM), stronger than those of the clinically used anticancer drug, 5-fluorouracil (IC50, 7.5 microM and 5.4 microM, respectively). Based on the observed results, the structure-activity relationships are discussed.
巻・号 5(10)
ページ 1601-6
公開日 2010-10-1
PMID 21121257
MeSH Animals Antineoplastic Agents / isolation & purification* Drug Screening Assays, Antitumor HeLa Cells Humans Mice Propolis / chemistry* Structure-Activity Relationship
IF 0.468
リソース情報
ヒト・動物細胞 HeLa(RCB0007) A549(RCB0098)