RRC ID 71636
著者 Nakamura E, Satoh T, Iwakawa M, Nakawatari M, Oki A, Matsumoto K, Okada S, Minaguchi T, Yoshikawa H, Imai T.
タイトル Villin1, a diagnostic marker for endometrial adenocarcinoma with high grade nuclear atypia.
ジャーナル Cancer Biol Ther
Abstract Villin1 (VIL1) has a role in regulating actin dynamics, cell morphology, anti-apoptotic mechanisms, and epithelial-to-mesenchymal transition. Previously we reported VIL1 as a novel diagnostic marker for cervical adenocarcinoma (AC) with poor radioresponse. This study further investigated the diagnostic role of VIL1 in gynecological tumors especially endometrial AC. We recruited 107 patients with AC (41 tumors in the corpus and 66 tumors in cervix), most of whom treated by total abdominal hysterectomy. Immunohistochemical analysis revealed VIL1-positive tumors in 37% of cases; 10 of 41 corpus tumors and 30 of 66 tumors in the cervix. VIL1-positive tumors were further examined histologically and immunostained for epithelial cell surface marker, EpCAM, and mesenchymal stem cell marker, CD44. Most of these tumors were CD44 negative and EpCAM positive, and the cytoplasmic VIL1 immunoreactivity in endometrial AC was more selective than EpCAM in reflecting histological aggressiveness with high grade nuclear atypia. This study confirmed our previous finding of VIL1 as a diagnostic marker of cervical AC. In addition, VIL1 immunostaining was detected in 25% of endometrial AC cases. These results suggested the existence of an aggressive and VIL1-positive subtype of gynecological tumor.
巻・号 12(3)
ページ 181-90
公開日 2011-8-1
DOI 10.4161/cbt.12.3.15964
PII 15964
PMID 21623163
MeSH Actins / metabolism Adenocarcinoma / diagnosis* Adenocarcinoma / pathology Aged Antigens, Neoplasm / analysis Antigens, Neoplasm / metabolism Biomarkers, Tumor / analysis* Cell Adhesion Molecules / analysis Cell Adhesion Molecules / metabolism Cell Line, Tumor Cytoplasm / metabolism Cytoskeleton / metabolism Endometrial Neoplasms / diagnosis* Endometrial Neoplasms / metabolism Endometrial Neoplasms / pathology Epithelial Cell Adhesion Molecule Female Humans Hyaluronan Receptors / analysis Hyaluronan Receptors / metabolism Microfilament Proteins / analysis* Middle Aged Radiation Tolerance Uterine Cervical Neoplasms / diagnosis* Uterine Cervical Neoplasms / metabolism Uterine Cervical Neoplasms / pathology
IF 3.659
リソース情報
ヒト・動物細胞 ME-180(RCB2106) HeLa(RCB0007)