論文 - 詳細
| RRC ID | 71679 |
|---|---|
| 著者 | Naito M, Umegaki H, Iguchi A. |
| タイトル | Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12. |
| ジャーナル | Neurosci Lett |
| Abstract |
The sympathetic nerve cell line PC12 is reportedly destroyed by glutamate in a concentration-dependent manner. In this study, cytotoxicity induced by 10 mM glutamate was blocked in a dose-dependent manner by incubating or pre-incubating cells with the antioxidant probucol (1-50 microM). Probucol also inhibited the increase in cellular thiobarbituric acid-reacting substances induced by glutamate exposure. These results suggest that the propagation of cellular lipid peroxidation may be related to glutamate-induced toxicity in PC12 cells. |
| 巻・号 | 186(2-3) |
| ページ | 211-3 |
| 公開日 | 1995-2-17 |
| DOI | 10.1016/0304-3940(95)11321-m |
| PII | 0304-3940(95)11321-M |
| PMID | 7777199 |
| MeSH | Animals Cell Survival / drug effects Excitatory Amino Acid Antagonists / pharmacology* Free Radicals / metabolism Glutamic Acid / toxicity* Lipid Peroxidation / drug effects Neurons / drug effects* PC12 Cells Probucol / pharmacology* Rats Thiobarbituric Acid Reactive Substances / metabolism |
| IF | 2.274 |
| リソース情報 | |
| ヒト・動物細胞 | PC-12(RCB0009) |