Reference - Detail
|Author||Naito M, Umegaki H, Iguchi A.|
|Title||Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12.|
The sympathetic nerve cell line PC12 is reportedly destroyed by glutamate in a concentration-dependent manner. In this study, cytotoxicity induced by 10 mM glutamate was blocked in a dose-dependent manner by incubating or pre-incubating cells with the antioxidant probucol (1-50 microM). Probucol also inhibited the increase in cellular thiobarbituric acid-reacting substances induced by glutamate exposure. These results suggest that the propagation of cellular lipid peroxidation may be related to glutamate-induced toxicity in PC12 cells.
|MeSH||Animals Cell Survival / drug effects Excitatory Amino Acid Antagonists / pharmacology* Free Radicals / metabolism Glutamic Acid / toxicity* Lipid Peroxidation / drug effects Neurons / drug effects* PC12 Cells Probucol / pharmacology* Rats Thiobarbituric Acid Reactive Substances / metabolism|
|Human and Animal Cells||PC-12(RCB0009)|