RRC ID 71679
Author Naito M, Umegaki H, Iguchi A.
Title Protective effects of probucol against glutamate-induced cytotoxicity in neuronal cell line PC12.
Journal Neurosci Lett
Abstract The sympathetic nerve cell line PC12 is reportedly destroyed by glutamate in a concentration-dependent manner. In this study, cytotoxicity induced by 10 mM glutamate was blocked in a dose-dependent manner by incubating or pre-incubating cells with the antioxidant probucol (1-50 microM). Probucol also inhibited the increase in cellular thiobarbituric acid-reacting substances induced by glutamate exposure. These results suggest that the propagation of cellular lipid peroxidation may be related to glutamate-induced toxicity in PC12 cells.
Volume 186(2-3)
Pages 211-3
Published 1995-2-17
DOI 10.1016/0304-3940(95)11321-m
PII 0304-3940(95)11321-M
PMID 7777199
MeSH Animals Cell Survival / drug effects Excitatory Amino Acid Antagonists / pharmacology* Free Radicals / metabolism Glutamic Acid / toxicity* Lipid Peroxidation / drug effects Neurons / drug effects* PC12 Cells Probucol / pharmacology* Rats Thiobarbituric Acid Reactive Substances / metabolism
IF 2.274
Human and Animal Cells PC-12(RCB0009)