RRC ID 71710
Author Bando T, Fujimura M, Kasahara K, Ueno T, Matsuda T.
Title Selective beta2-adrenoceptor agonist enhances sensitivity to cisplatin in non-small cell lung cancer cell line.
Journal Oncol Rep
Abstract Cisplatin is a key drug in chemotherapy for lung cancer. It has been reported that intracellular accumulation of cisplatin is an important step as a determinant for resistance to cisplatin, which may be modulated by Na+, K+-ATPase activity. And it has been reported that isoproterenol, a beta-adrenoceptor agonist, enhances sensitivity to cisplatin in non-small cell lung cancer (NSCLC) cell lines. In this study, the effects of the selective beta1, beta2, and beta3-adrenoceptor agonists on membrane Na+, K+-ATPase activity and sensitivity to cisplatin were evaluated using human non-small cell lung cancer cell line. In the NSCLC cell line, sensitivity to cisplatin was improved by treatment with procaterol, a selective beta2-adrenoceptor agonist. Na+, K+-ATPase was activated and intracellular accumulation of cisplatin increased with the treatment. However, beta1 or beta3-adrenoceptor agonist did not modulate sensitivity to cisplatin or Na+, K+-ATPase activity. These results suggest that beta2-adrenoceptor may be one of the determinants for sensitivity to cisplatin in NSCLC. Exogenous beta2-adrenoceptor agonists may improve the antitumor effect of chemotherapy involving cisplatin.
Volume 7(1)
Pages 49-52
Published 2000-1-1
DOI 10.3892/or.7.1.49
PMID 10601590
MeSH Adrenergic beta-2 Receptor Agonists* Adrenergic beta-Agonists / pharmacology* Antineoplastic Agents / pharmacology* Carcinoma, Non-Small-Cell Lung / drug therapy* Carcinoma, Non-Small-Cell Lung / pathology Catechols / pharmacology Cisplatin / pharmacokinetics Cisplatin / pharmacology* Drug Synergism Ethanolamines / pharmacology Humans Lung Neoplasms / drug therapy* Lung Neoplasms / pathology Potassium / metabolism Procaterol / pharmacology* Serine / analogs & derivatives Serine / pharmacology Sodium-Potassium-Exchanging ATPase / metabolism Tumor Cells, Cultured
IF 3.417
Human and Animal Cells EBC-1(RCB1965)