論文 - 詳細
| RRC ID | 71720 |
|---|---|
| 著者 | Xue R, Han N, Ye C, Wang HB, Yin J. |
| タイトル | Cardenolide glycosides from root of Streptocaulon juventas. |
| ジャーナル | Phytochemistry |
| Abstract |
Six cardenolides were isolated from the anti-tumor active fraction of the 75% ethanol extract of Streptocaulon juventas (Asclepiadaceae), mainly found in southwest of China. These were named 1α, 14β-dihydroxy-5β-card-20 (22)-enolide 3-O-[O-β-D-glucopyranosyl-(1→2)-β-D-digitalopyranoside] (1), acovenosigenin A 3-O-[O-β-D-glucopyranosyl-(1→4)-β-D-digitalopyranoside] (2), 16-O-acetyl-hydroxyperiplogenin 3-O-β-D-digitoxopyranoside (3), digitoxigenin 3-O-[O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-(1→4)-2-O-acetyl-β-D-digitalopyranoside] (4), 16-O-acetyl-hydroxyacovenosigenin (5), 1β, 3β, 14β-trihydroxy-5β-card-16, 20 (22)-dienolide (6), together with 18 known ones, most of which had never been reported in the species beforehand. Their structures were elucidated on the basis of spectroscopic studies and comparison with reference. Eighteen compounds were evaluated for their cytotoxicity against human lung A549 adenocarcinoma cell lines. |
| 巻・号 | 88 |
| ページ | 105-11 |
| 公開日 | 2013-4-1 |
| DOI | 10.1016/j.phytochem.2012.12.004 |
| PII | S0031-9422(12)00524-9 |
| PMID | 23286880 |
| MeSH | Antineoplastic Agents / chemistry Antineoplastic Agents / pharmacology Cardenolides / chemistry* Cardenolides / pharmacology Cell Line, Tumor Cell Survival / drug effects Doxorubicin / pharmacology Glycosides / chemistry* Glycosides / pharmacology Humans Magnetic Resonance Spectroscopy Molecular Structure Neoplasms / drug therapy Plant Roots / chemistry* |
| IF | 3.057 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| ヒト・動物細胞 | A549(RCB0098) |