Reference - Detail
| RRC ID | 71846 |
|---|---|
| Author | Mungroo MR, Tong T, Khan NA, Anuar TS, Maciver SK, Siddiqui R. |
| Title | Development of anti-acanthamoebic approaches. |
| Journal | Int Microbiol |
| Abstract |
Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications. |
| Volume | 24(3) |
| Pages | 363-371 |
| Published | 2021-8-1 |
| DOI | 10.1007/s10123-021-00171-3 |
| PII | 10.1007/s10123-021-00171-3 |
| PMID | 33754231 |
| MeSH | Acanthamoeba Keratitis / drug therapy* Acanthamoeba Keratitis / parasitology* Acanthamoeba castellanii / drug effects* Acarbose / pharmacology Antiprotozoal Agents / pharmacology* Carbamates / pharmacology Cell Line Contact Lens Solutions / pharmacology Contact Lenses / adverse effects Contact Lenses / parasitology* HaCaT Cells Humans Indenes / pharmacology Inositol / pharmacology Nanoparticles Piperidines / pharmacology Sulfonylurea Compounds / pharmacology Triazines / pharmacology Vildagliptin / pharmacology |
| IF | 1.833 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HCE-T(RCB2280) |