論文 - 詳細
| RRC ID | 72306 |
|---|---|
| 著者 | Kong D, Zhao S, Xu W, Dong J, Ma X. |
| タイトル | Fat body-derived Spz5 remotely facilitates tumor-suppressive cell competition through Toll-6-α-Spectrin axis-mediated Hippo activation. |
| ジャーナル | Cell Rep |
| Abstract |
Tumor-suppressive cell competition is an evolutionarily conserved process that selectively removes precancerous cells to maintain tissue homeostasis. Using the polarity-deficiency-induced cell competition model in Drosophila, we identify Toll-6, a Toll-like receptor family member, as a driver of tension-mediated cell competition through α-Spectrin (α-Spec)-Yorkie (Yki) cascade. Toll-6 aggregates along the boundary between wild-type and polarity-deficient clones, where Toll-6 physically interacts with the cytoskeleton network protein α-Spec to increase mechanical tension, resulting in actomyosin-dependent Hippo pathway activation and the elimination of scrib mutant cells. Furthermore, we show that Spz5 secreted from fat body, the key innate organ in fly, facilitates the elimination of scrib clones by binding to Toll-6. These findings uncover mechanisms by which fat bodies remotely regulate tumor-suppressive cell competition of polarity-deficient tumors through inter-organ crosstalk and identified the Toll-6-α-Spec axis as an essential guardian that prevents tumorigenesis via tension-mediated cell elimination. |
| 巻・号 | 39(12) |
| ページ | 110980 |
| 公開日 | 2022-6-21 |
| DOI | 10.1016/j.celrep.2022.110980 |
| PII | S2211-1247(22)00766-5 |
| PMID | 35732124 |
| MeSH | Animals Cell Competition Drosophila / metabolism Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Fat Body / metabolism Signal Transduction / physiology Spectrin / metabolism |
| IF | 8.109 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | Cat# 9774R-3 |