Reference - Detail
| RRC ID | 72316 |
|---|---|
| Author | Saito S, Suzuki S, Arai MA. |
| Title | Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41. |
| Journal | J Antibiot (Tokyo) |
| Abstract |
The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a "heat shock metabolite" (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration. |
| Volume | 75(9) |
| Pages | 509-513 |
| Published | 2022-9-1 |
| DOI | 10.1038/s41429-022-00551-5 |
| PII | 10.1038/s41429-022-00551-5 |
| PMID | 35918479 |
| MeSH | Heat-Shock Response Oxazoles / metabolism Streptomyces* / metabolism Thermotolerance* |
| IF | 2.668 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Human and Animal Cells | HL-60(RCB3683) |