| RRC ID |
72316
|
| Author |
Saito S, Suzuki S, Arai MA.
|
| Title |
Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously designated this type of compound as a "heat shock metabolite" (HSM). NMR and MS analytical techniques were used to determine that the chemical structure of 1 comprised a methylated-oxazole ring and a linear chain moiety modified with a terminal amide group. Thus, 1 was shown to be a new curromycin analog, which we have designated noaoxazole (1). Compound 1 weakly activated Notch signal reporter activity without exhibiting cytotoxicity against assay cells at the same concentration.
|
| Volume |
75(9)
|
| Pages |
509-513
|
| Published |
2022-9-1
|
| DOI |
10.1038/s41429-022-00551-5
|
| PII |
10.1038/s41429-022-00551-5
|
| PMID |
35918479
|
| MeSH |
Heat-Shock Response
Oxazoles / metabolism
Streptomyces* / metabolism
Thermotolerance*
|
| IF |
2.668
|
| Resource |
| Human and Animal Cells |
HL-60(RCB3683) |
