| RRC ID |
72537
|
| 著者 |
Murata K, Abe Y, Futamura-Masudaa M, Uwaya A, Isami F, Matsuda H.
|
| タイトル |
Activation of cell-mediated immunity by Morinda citrifolia fruit extract and its constituents.
|
| ジャーナル |
Nat Prod Commun
|
| Abstract |
Morinda citrifolia, commonly known as noni, is a traditional natural medicine in French Polynesia and Hawaii. Functional foods derived from M. citrifolia fruit have been marketed to help prevent diseases and promote good health. The objective of this study was to assess the effects of M. citrifolia fruit on cell-mediated immunity. In the picryl chloride-induced contact dermatitis test, M. citrifolia fruit extract (Noni-ext) inhibited the suppression of cell-mediated immunity by immunosuppressive substances isolated from freeze-dried ascites of Ehrlich carcinoma-bearing mice (EC-sup). In addition, Noni-ext inhibited reduction of IL-2 production in EC-sup-treated mice and activated natural killer cells in normal mice. These results suggest that Noni-ext has multiple effects on the recovery of cell-mediated immunity. Furthermore, we investigated the active principles of Noni-ext and identified an iridoid glycoside, deacetylasperulosidic acid. Oral administration of deacetylasperulosidic acid inhibited the reduction of ear swelling, and also cancelled the suppression of IL-2 production along with the activation of natural killer cells in the same manner as that of Noni-ext.
|
| 巻・号 |
9(4)
|
| ページ |
445-50
|
| 公開日 |
2014-4-1
|
| PMID |
24868850
|
| MeSH |
Animals
Cytokines / genetics
Cytokines / metabolism
Female
Fruit / chemistry*
Gene Expression Regulation / drug effects
Immunity, Cellular / drug effects*
Inflammation / drug therapy
Killer Cells, Natural / drug effects
Killer Cells, Natural / physiology
Mice
Mice, Inbred BALB C
Mice, Inbred ICR
Morinda / chemistry*
Picryl Chloride / toxicity
Plant Extracts / chemistry
Plant Extracts / pharmacology*
Spleen / cytology
T-Lymphocyte Subsets / drug effects
|
| IF |
0.468
|
| リソース情報 |
| ヒト・動物細胞 |
YAC-1(RCB1165) |
