RRC ID 72633
Author Kurimoto S, Pu JX, Sun HD, Shibata H, Takaishi Y, Kashiwada Y.
Title Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae).
Journal J Nat Med
Abstract Twenty new neo-clerodane type diterpenoids, scutefolides G1-S (1-20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus.
Volume 70(2)
Pages 241-52
Published 2016-4-1
DOI 10.1007/s11418-016-0967-3
PII 10.1007/s11418-016-0967-3
PMID 26825781
Human and Animal Cells MCF7(RCB1904) A549(RCB0098) HeLa(RCB0007)