論文 - 詳細
| RRC ID | 72633 |
|---|---|
| 著者 | Kurimoto S, Pu JX, Sun HD, Shibata H, Takaishi Y, Kashiwada Y. |
| タイトル | Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae). |
| ジャーナル | J Nat Med |
| Abstract |
Twenty new neo-clerodane type diterpenoids, scutefolides G1-S (1-20), were isolated from the 70 % aqueous acetone extract of the aerial parts of Scutellaria coleifolia. Their structures were elucidated by extensive spectroscopic analyses. The absolute configurations of 1, 2, 7, 8, 14 and 15 were determined by means of the CD exciton chirality method. Compounds 1, 2, 5, 7, 8, 12, 14, 15, 18 and 19 were evaluated for their cytotoxic activities against four human cancer cell lines, and anti-bacterial activities against methicillin-resistant Staphylococcus aureus. |
| 巻・号 | 70(2) |
| ページ | 241-52 |
| 公開日 | 2016-4-1 |
| DOI | 10.1007/s11418-016-0967-3 |
| PII | 10.1007/s11418-016-0967-3 |
| PMID | 26825781 |
| MeSH | Acylation Cell Line, Tumor Diterpenes, Clerodane / chemistry Diterpenes, Clerodane / isolation & purification* Diterpenes, Clerodane / pharmacology Humans Methicillin-Resistant Staphylococcus aureus / drug effects Molecular Structure Neoplasms Plant Components, Aerial / chemistry Plant Extracts / chemistry* Plant Extracts / pharmacology Scutellaria / chemistry* |
| IF | 2.055 |
| リソース情報 | |
| ヒト・動物細胞 | MCF7(RCB1904) A549(RCB0098) HeLa(RCB0007) |