| RRC ID |
72651
|
| 著者 |
Fadlan A, Tanimoto H, Ito T, Aritomi Y, Ueno M, Tokuda M, Hirohara S, Obata M, Morimoto T, Kakiuchi K.
|
| タイトル |
Synthesis, photophysical properties, and photodynamic activity of positional isomers of TFPP-glucose conjugates.
|
| ジャーナル |
Bioorg Med Chem
|
| Abstract |
The synthesis and characterization of a 'complete set' of positional isomers of tetrakis(perfluorophenyl)porphyrins (TFPP)-glucose conjugates (1OH, 2OH, 3OH, 4OH, and 6OH) are reported herein. The cellular uptake and photocytotoxicity of these conjugates were examined in order to investigate the influence of location of the TFPP moiety on the d-glucose molecule on the biological activity of the conjugates. An In vitro biological evaluation revealed that the certain of these isomers have a greater effect on cellular uptake and cytotoxicity than others. The TFPP-glucose conjugates 1OH, 3OH, and 4OH were found to exert exceptional photocytotoxicity in several types of cancer cells compared to 2OH and 6OH substituted isomers.
|
| 巻・号 |
26(8)
|
| ページ |
1848-1858
|
| 公開日 |
2018-5-1
|
| DOI |
10.1016/j.bmc.2018.02.031
|
| PII |
S0968-0896(17)32442-2
|
| PMID |
29496414
|
| MeSH |
Cell Line, Tumor
Cell Survival / drug effects
Glucose / chemistry*
Humans
Isomerism
Light
Photochemotherapy
Photosensitizing Agents / chemical synthesis*
Photosensitizing Agents / pharmacology
Photosensitizing Agents / therapeutic use
Porphyrins / chemistry*
Stomach Neoplasms / drug therapy
|
| IF |
3.073
|
| リソース情報 |
| ヒト・動物細胞 |
HeLa |
