論文 - 詳細
| RRC ID | 72654 |
|---|---|
| 著者 | Chen Y, Xu W, Chen Y, Han A, Song J, Zhou X, Song W. |
| タイトル | Renal NF-κB activation impairs uric acid homeostasis to promote tumor-associated mortality independent of wasting. |
| ジャーナル | Immunity |
| Abstract |
Tumor-induced host wasting and mortality are general phenomena across species. Many groups have previously demonstrated endocrinal impacts of malignant tumors on host wasting in rodents and Drosophila. Whether and how environmental factors and host immune response contribute to tumor-associated host wasting and survival, however, are largely unknown. Here, we report that flies bearing malignant yki3SA-gut tumors exhibited the exponential increase of commensal bacteria, which were mostly acquired from the environment, and systemic IMD-NF-κB activation due to suppression of a gut antibacterial amidase PGRP-SC2. Either gut microbial elimination or specific IMD-NF-κB blockade in the renal-like Malpighian tubules potently improved mortality of yki3SA-tumor-bearing flies in a manner independent of host wasting. We further indicate that renal IMD-NF-κB activation caused uric acid (UA) overload to reduce survival of tumor-bearing flies. Therefore, our results uncover a fundamental mechanism whereby gut commensal dysbiosis, renal immune activation, and UA imbalance potentiate tumor-associated host death. |
| 巻・号 | 55(9) |
| ページ | 1594-1608.e6 |
| 公開日 | 2022-9-13 |
| DOI | 10.1016/j.immuni.2022.07.022 |
| PII | S1074-7613(22)00357-0 |
| PMID | 36029766 |
| MeSH | Animals Carrier Proteins Drosophila Homeostasis NF-kappa B* / metabolism Neoplasms* Uric Acid |
| IF | 22.553 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 21 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 14745R-1 7103R-1 |