論文 - 詳細
| RRC ID | 72656 |
|---|---|
| 著者 | Deliu LP, Turingan M, Jadir D, Lee B, Ghosh A, Grewal SS. |
| タイトル | Serotonergic neuron ribosomal proteins regulate the neuroendocrine control of Drosophila development. |
| ジャーナル | PLoS Genet |
| Abstract |
The regulation of ribosome function is a conserved mechanism of growth control. While studies in single cell systems have defined how ribosomes contribute to cell growth, the mechanisms that link ribosome function to organismal growth are less clear. Here we explore this issue using Drosophila Minutes, a class of heterozygous mutants for ribosomal proteins. These animals exhibit a delay in larval development caused by decreased production of the steroid hormone ecdysone, the main regulator of larval maturation. We found that this developmental delay is not caused by decreases in either global ribosome numbers or translation rates. Instead, we show that they are due in part to loss of Rp function specifically in a subset of serotonin (5-HT) neurons that innervate the prothoracic gland to control ecdysone production. We find that these effects do not occur due to altered protein synthesis or proteostasis, but that Minute animals have reduced expression of synaptotagmin, a synaptic vesicle protein, and that the Minute developmental delay can be partially reversed by overexpression of synaptic vesicle proteins in 5-HTergic cells. These results identify a 5-HT cell-specific role for ribosomal function in the neuroendocrine control of animal growth and development. |
| 巻・号 | 18(9) |
| ページ | e1010371 |
| 公開日 | 2022-9-1 |
| DOI | 10.1371/journal.pgen.1010371 |
| PII | PGENETICS-D-22-00182 |
| PMID | 36048889 |
| PMC | PMC9473637 |
| MeSH | Animals Drosophila* / genetics Drosophila Proteins* / metabolism Drosophila melanogaster / metabolism Ecdysone / metabolism Gene Expression Regulation, Developmental Larva Ribosomal Proteins / genetics Ribosomal Proteins / metabolism Serotonergic Neurons / metabolism Serotonin / genetics Serotonin / metabolism |
| IF | 5.175 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 5 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#141848 |