| RRC ID |
72763
|
| 著者 |
Takeyama H, Maruta M, Sato T, Kajimoto N, Fujii E, Matsuura T, Tsuru K.
|
| タイトル |
Fabrication of bioresorbable hydroxyapatite bone grafts through the setting reaction of calcium phosphate cement.
|
| ジャーナル |
Dent Mater J
|
| Abstract |
We prepared hydroxyapatite (HAp) bone grafts by the setting reaction of calcium phosphate cement, and investigated the effects of the porosity and crystallinity on the osteoconductivity and bioresorbability. We examined the effect of the water-mixing ratio, pressure, and post-heat treatment temperature during preparation on the crystallite size and porosity of the HAp blocks. The quantity of protein adsorption increased with increasing porosity and specific surface area (SSA) of the HAp blocks, whereas the initial cell attachment was similar despite the different porosities and crystallinities. In in vitro dissolution tests with a pH 5.5 buffer, which mimics an osteoclast-created Howship's lacuna, both the porosity and SSA of the HAp blocks affected the solubility; most likely due to the increased contact area with the buffer. Thus, HAp blocks prepared by the setting reaction of calcium phosphate cement could be applicable for bioresorbable HAp bone grafts because of the high porosity and SSA.
|
| 巻・号 |
41(6)
|
| ページ |
882-888
|
| 公開日 |
2022-11-30
|
| DOI |
10.4012/dmj.2022-045
|
| PMID |
36002294
|
| MeSH |
Absorbable Implants*
Bone Cements
Calcium Phosphates
Dental Cements
Dental Materials
Durapatite*
Glass Ionomer Cements
Porosity
|
| IF |
1.359
|
| リソース情報 |
| ヒト・動物細胞 |
MC3T3-E1(RCB1126) |
