論文 - 詳細
| RRC ID | 72844 |
|---|---|
| 著者 | Inoue S, Orimo A, Hosoi T, Kondo S, Toyoshima H, Kondo T, Ikegami A, Ouchi Y, Orimo H, Muramatsu M. |
| タイトル | Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
Estrogen receptor (ER)-binding fragments were isolated from human genomic DNA by using a recombinant ER protein. Using one of these fragments as a probe, we have identified an estrogen-responsive gene that encodes a putative zinc finger protein. It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp). efp cDNA contains a consensus estrogen-responsive element at the 3' untranslated region that can act as a downstream estrogen-dependent enhancer. Moreover, efp is regulated by estrogen as demonstrated at both the mRNA and the protein level in ER-positive cells derived from mammary gland. These data suggest that efp may represent an estrogen-responsive transcription factor that mediates phenotypic expression of the diverse estrogen action. Thus, the genomic binding-site cloning may be applicable for isolation of the target genes of other transcription factors. |
| 巻・号 | 90(23) |
| ページ | 11117-21 |
| 公開日 | 1993-12-1 |
| DOI | 10.1073/pnas.90.23.11117 |
| PMID | 8248217 |
| PMC | PMC47933 |
| MeSH | Amino Acid Sequence Base Sequence Blotting, Northern Blotting, Western Cloning, Molecular Consensus Sequence DNA, Complementary / genetics DNA-Binding Proteins / chemistry DNA-Binding Proteins / genetics* Gene Expression Gene Expression Regulation Genes Molecular Sequence Data Molecular Weight RNA, Messenger / genetics Receptors, Estrogen / genetics* Regulatory Sequences, Nucleic Acid Sequence Alignment Sequence Homology, Amino Acid Transcription Factors / chemistry Transcription Factors / genetics* Zinc Fingers* |
| IF | 9.412 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 16 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HBL-100(RCB0460) |