| RRC ID |
72863
|
| 著者 |
Xu G, Fujita J, Negayama K, Yuube K, Hojo S, Yamaji Y, Kawanishi K, Takahara J.
|
| タイトル |
Effect of macrolide antibiotics on macrophage functions.
|
| ジャーナル |
Microbiol Immunol
|
| Abstract |
Macrolide antibiotics have a variety of actions other than antimicrobial activities. Recently, it has been suggested that macrolide antibiotics act as immunomodulators. In this study, we evaluated the effects of macrolide antibiotics on macrophage functions. For the macrophage, we used the mouse macrophage cell line J774.1. The following effects of macrolide antibiotics on macrophage functions were evaluated: the effect of macrolide antibiotics on macrophage growth; the phagocytosis of beads; cytocidal activity against Candida albicans; and chemotaxis to lipopolysaccharide (LPS). Macrolide antibiotics except for azithromycin significantly stimulated the growth of the macrophage. In addition, pretreatment with macrolide antibiotics except for roxithromycin significantly stimulated the macrophage phagocytosis of beads, macrophage chemotaxis to LPS, and macrophage cytocidal activity against Candida albicans. These results suggest that macrolide antibiotics stimulate macrophage functions.
|
| 巻・号 |
40(7)
|
| ページ |
473-9
|
| 公開日 |
1996-1-1
|
| DOI |
10.1111/j.1348-0421.1996.tb01097.x
|
| PMID |
8865152
|
| MeSH |
Animals
Anti-Bacterial Agents / pharmacology*
Azithromycin / pharmacology
Cell Line
Chemotaxis / drug effects
Clarithromycin / pharmacology
Cytotoxicity, Immunologic / drug effects
Dose-Response Relationship, Drug
Erythromycin / analogs & derivatives*
Erythromycin / pharmacology*
Macrophages / drug effects*
Macrophages / immunology
Mice
Phagocytosis / drug effects
Roxithromycin / pharmacology
|
| IF |
1.566
|
| リソース情報 |
| ヒト・動物細胞 |
J774.1(RCB0434) |
