| RRC ID |
72876
|
| 著者 |
Yoneda Y, Yahagi T, Harada K, Okamoto Y, Motai S, Matsuzaki K, Kubo M, Fukuyama Y, Ohsaki A.
|
| タイトル |
Anchietins A-E: 30-norfriedelane-type triterpenes from Anchietea pyrifolia.
|
| ジャーナル |
Phytochemistry
|
| Abstract |
Five undescribed norfriedelane triterpenoids, anchietins A-E, along with three known norfriedelane triterpenoids, 21β-hydroxycaloncobalactone, and welwitschiilactones B and C, were isolated from the vine of Anchietia pyrifolia. The compounds were characterized by spectroscopic and crystallographic methods, including 2D NMR spectroscopy and single crystal X-ray crystallography. The isolated compounds were evaluated for the cytotoxic activity against HeLa and HL60 cells and for the inhibitory activity against lipopolysaccharide-induced NO production. Further, inhibitory effects on the inducible nitric oxide synthase mRNA expression levels were also assessed.
|
| 巻・号 |
203
|
| ページ |
113388
|
| 公開日 |
2022-11-1
|
| DOI |
10.1016/j.phytochem.2022.113388
|
| PII |
S0031-9422(22)00304-1
|
| PMID |
36075316
|
| MeSH |
Lipopolysaccharides / pharmacology
Molecular Structure
Nitric Oxide / metabolism
Nitric Oxide Synthase Type II / metabolism
RNA, Messenger
Triterpenes* / chemistry
Triterpenes* / pharmacology
|
| IF |
3.044
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041)
HeLa(RCB0007) |
