Reference - Detail
| RRC ID | 72886 |
|---|---|
| Author | Iizuka H, Watanabe Y, Kojima S. |
| Title | Effect of 5,6,7,8-tetrahydroneopterin on oxidative modification of low-density lipoprotein, and its uptake in the macrophage-like cell line J774. |
| Journal | Jpn J Pharmacol |
| Abstract |
Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5,6,7,8-tetrahydroneopterin (NPH4) on Cu(II)-induced lipid peroxidation of LDL. NPH4 significantly inhibited both lipid peroxidation and the associated increase of electrophoretic mobility of ApoB protein. Furthermore, NPH4 suppressed the uptake of oxidized [14C]oleyl-esterified LDL by the macrophage-like cell line J774. NPH4 may be a candidate for the treatment of atherosclerosis and other active oxygen-related diseases. |
| Volume | 72(4) |
| Pages | 375-9 |
| Published | 1996-12-1 |
| DOI | 10.1254/jjp.72.375 |
| PMID | 9015746 |
| MeSH | Antioxidants / pharmacology* Apolipoproteins B / chemistry Biopterin / analogs & derivatives* Biopterin / pharmacology Blood Protein Electrophoresis Cell Line Copper / pharmacology Humans Lipid Peroxidation / drug effects Lipoproteins, LDL / metabolism* Macrophages / drug effects Macrophages / metabolism* Oxidation-Reduction Phosphatidylcholines / metabolism |
| Resource | |
| Human and Animal Cells | J774.1(RCB0434) |