| RRC ID |
72917
|
| Author |
Yanagawa K, Yamashita T, Yada K, Ohira M, Ishikawa T, Yano Y, Otani S, Sowa M.
|
| Title |
The antiproliferative effect of HGF on hepatoma cells involves induction of apoptosis with increase in intracellular polyamine concentration levels.
|
| Journal |
Oncol Rep
|
| Abstract |
Hepatocyte growth factor (HGF) induced apoptosis and decreased the DNA synthesis in Hep G2 cells. In the HGF group interleukin-1 converting enzyme, ornithine decarboxylase (ODC) activity and intracellular polyamine concentrations were increased compared to those of the control group. Administration of the ODC inhibitor decreased polyamine concentration, and inhibited apoptotic changes in the cells. These changes were reversed by exogenous addition of polyamine. These findings suggest that one of the mechanisms by which HGF exerts its antiproliferative effect is induction of apoptosis and that increase in intracellular polyamine concentration may be one of the triggers of cell death.
|
| Volume |
5(1)
|
| Pages |
185-90
|
| Published |
1998-1-1
|
| PMID |
9458319
|
| MeSH |
Apoptosis / drug effects
Apoptosis / physiology*
Carcinoma, Hepatocellular / pathology*
Caspase 1
Cysteine Endopeptidases / metabolism
DNA Fragmentation
DNA, Neoplasm / biosynthesis
Eflornithine / pharmacology
Hepatocyte Growth Factor / pharmacology*
Humans
Kinetics
Liver Neoplasms / pathology*
Ornithine Decarboxylase / metabolism*
Polyamines / metabolism*
Putrescine / pharmacology
Spermidine / pharmacology
Tumor Cells, Cultured
|
| IF |
3.417
|
| Resource |
| Human and Animal Cells |
Hep G2(RCB0459) |
