| RRC ID |
72954
|
| Author |
Kikuchi T, Okada R, Harada Y, Ikushima K, Yamakawa T, Yamada T, Tanaka R.
|
| Title |
Cucurbitane-type triterpenes from Citrullus lanatus (watermelon) seeds.
|
| Journal |
Nat Prod Commun
|
| Abstract |
Two new cucurbitane-type triterpenes, 24-hydroperoxycucurbita-5,25-dien-3beta-ol (1) and 25-hydroperoxycucurbita-5,23-dien-3beta-ol (2), were isolated from a MeOH extract of Citrullus lanatus seeds. Compounds 1 and 2 exhibited moderate cytotoxic activities with IC50 values of 33.4-52.4 microM against HL-60 (human leukemia), P388 (murine leukemia), and L1210 (murine leukemia) cells. Compound 1 showed melanogenesis inhibitory activity (melanin content 80.0 %) with low cytotoxicity (cell viability 97.6%) at a low concentration (10 microM).
|
| Volume |
8(10)
|
| Pages |
1367-9
|
| Published |
2013-10-1
|
| PMID |
24354176
|
| MeSH |
Animals
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Citrullus / chemistry*
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Mice
Molecular Structure
Plants, Medicinal / chemistry
Seeds / chemistry
Triterpenes / chemistry
Triterpenes / isolation & purification*
|
| IF |
0.468
|
| Resource |
| Human and Animal Cells |
B16 melanoma 4A5(RCB0557) |
