論文 - 詳細
| RRC ID | 72961 |
|---|---|
| 著者 | Kumawat M, Madhyastha H, Singh M, Revaprasadu N, Srinivas SP, Daima HK. |
| タイトル | Double functionalized haemocompatible silver nanoparticles control cell inflammatory homeostasis. |
| ジャーナル | PLoS One |
| Abstract |
Infection, trauma, and autoimmunity trigger tissue inflammation, often leading to pain and loss of function. Therefore, approaches to control inflammation based on nanotechnology principles are being developed in addition to available methods. The metal-based nanoparticles are particularly attractive due to the ease of synthesis, control over physicochemical properties, and facile surface modification with different types of molecules. Here, we report curcumin conjugated silver (Cur-Ag) nanoparticles synthesis, followed by their surface functionalization with isoniazid, tyrosine, and quercetin, leading to Cur-AgINH, Cur-AgTyr, and Cur-AgQrc nanoparticles, respectively. These nanoparticles possess radical scavenging capacity, haemocompatibility, and minimal cytotoxicity to macrophages. Furthermore, the nanoparticles inhibited the secretion of pro-inflammatory cytokines such as interleukin-6, tumor necrosis factor-α, and interleukin-1β from macrophages stimulated by lipopolysaccharide (LPS). The findings reveal that the careful design of surface corona of nanoparticles could be critical to increasing their efficacy in biomedical applications. |
| 巻・号 | 17(10) |
| ページ | e0276296 |
| 公開日 | 2022-1-1 |
| DOI | 10.1371/journal.pone.0276296 |
| PII | PONE-D-22-07408 |
| PMID | 36269783 |
| PMC | PMC9586410 |
| MeSH | Curcumin* / pharmacology Cytokines / metabolism Homeostasis Humans Inflammation Interleukin-1beta Interleukin-6 Isoniazid Lipopolysaccharides Metal Nanoparticles* / chemistry Nanoparticles* / chemistry Quercetin / pharmacology Silver / chemistry Silver / pharmacology Tumor Necrosis Factor-alpha Tyrosine |
| IF | 2.74 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | RAW 264(RCB0535) |