RRC ID 73
著者 Tsunenari I, Yamate J, Iwaki M, Kuwamura M, Kotani T, Sakuma S.
タイトル Angioarchitecture of tumors induced by two different cloned cell lines established from a transplantable rat malignant fibrous histiocytoma.
ジャーナル Microsc Microanal
Abstract Angiogenesis, a biologic process whereby endothelial cells divide and migrate to form new blood vessels, is a key step in tumor growth, invasion, and metastasis. In the present study, we investigated the differences in angioarchitecture between two different tumors induced by cloned cell lines (MT-8 and MT-9), derived from a transplantable rat malignant fibrous histiocytoma, by scanning electron microscopy of vascular corrosion casts. During a 3-week observation period after implantation, the growth of MT-8 tumors appeared to be faster than that of MT-9 tumors. Histologically, MT-8 tumors were of the uniformly undifferentiated sarcoma type arranged in characteristic organoid structures, and MT-9 tumors showed a storiform growth pattern. In MT-8 tumors, neovascularization occurred by sprouting at postimplantation (PI) week 1, and the newly formed capillaries gradually became more tortuous. In MT-9 tumors, at PI week 1, the corrosion casts of newly formed capillaries mainly showed a wavy course but no finger-like outgrowths of capillaries were seen. At PI weeks 2 and 3, the sprouting was seen specifically in MT-9 tumors, forming basket-like structures and glomeruloid structures of capillaries. These results indicate that angiogenesis or angioarchitecture of MT-8 tumors is different from that of MT-9 tumors, depending on the differences in their tumor histology and by the features like absence or presence of basket-like structures and glomeruloid structures of capillaries.
巻・号 9(6)
ページ 532-41
公開日 2003-12-1
DOI 10.1017/S1431927603030289
PII S1431927603030289
PMID 14750988
MeSH Animals Cell Division Clone Cells Histiocytoma, Benign Fibrous / blood supply* Histiocytoma, Benign Fibrous / pathology* Histiocytoma, Benign Fibrous / ultrastructure Image Processing, Computer-Assisted / methods Microscopy, Electron, Scanning / methods Neoplasm Transplantation Neovascularization, Pathologic / pathology* Rats Rats, Inbred F344 Tumor Cells, Cultured
IF 3.414
引用数 3
WOS 分野 MICROSCOPY MATERIALS SCIENCE, MULTIDISCIPLINARY
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