| RRC ID |
73005
|
| 著者 |
Matsuhashi R, Satou T, Koike K, Yokosuka A, Mimaki Y, Sashida Y, Nikaido T.
|
| タイトル |
Nematocidal activity of isoquinoline alkaloids against a species of diplogastridae.
|
| ジャーナル |
Planta Med
|
| Abstract |
We examined the nematocidal activity of various isoquinoline alkaloids. The method of evaluating nematocidal activity involved the microscopic examination of the state of larvae after the compound was administered to determine the minimum lethal concentration (MLC). In addition, cytotoxic activity (IC50) was examined using HL-60 culture cells. The compound dehydrocorydaline was found to have considerable nematocidal activity and weak cytotoxicity; its cytotoxicity value was equal to that of thiabendazole. We conclude that dehydrocorydaline, with its attractive balance between nematocidal activity and weak cytotoxicity, is the most promising of the tested compounds as a possible remedy for parasitic diseases.
|
| 巻・号 |
68(2)
|
| ページ |
169-71
|
| 公開日 |
2002-2-1
|
| DOI |
10.1055/s-2002-20249
|
| PMID |
11859472
|
| MeSH |
Alkaloids / isolation & purification
Alkaloids / pharmacology*
Animals
Antinematodal Agents / pharmacology*
Drugs, Chinese Herbal
HL-60 Cells
Humans
Inhibitory Concentration 50
Isoquinolines / isolation & purification
Isoquinolines / pharmacology*
Nematoda / drug effects*
Papaveraceae*
Thiabendazole / pharmacology
|
| IF |
2.687
|
| リソース情報 |
| ヒト・動物細胞 |
HL60(RCB0041) |
