論文 - 詳細
| RRC ID | 73094 |
|---|---|
| 著者 | Csizmadia T, Dósa A, Farkas E, Csikos BV, Kriska EA, Juhász G, Lőw P. |
| タイトル | Developmental program-independent secretory granule degradation in larval salivary gland cells of Drosophila. |
| ジャーナル | Traffic |
| Abstract |
Both constitutive and regulated secretion require cell organelles that are able to store and release the secretory cargo. During development, the larval salivary gland of Drosophila initially produces high amount of glue-containing small immature secretory granules, which then fuse with each other and reach their normal 3-3.5 μm in size. Following the burst of secretion, obsolete glue granules directly fuse with late endosomes or lysosomes by a process called crinophagy, which leads to fast degradation and recycling of the secretory cargo. However, hindering of endosome-to-TGN retrograde transport in these cells causes abnormally small glue granules which are not able to fuse with each other. Here we show that loss of function of the SNARE genes Syntaxin 16 (Syx16) and Synaptobrevin (Syb), the small GTPase Rab6 and the GARP tethering complex members Vps53 and Scattered (Vps54) all involved in retrograde transport causes intense early degradation of immature glue granules via crinophagy independently of the developmental program. Moreover, silencing of these genes also provokes secretory failure and accelerated crinophagy during larval development. Our results provide a better understanding of the relations among secretion, secretory granule maturation and degradation and paves the way for further investigation of these connections in other metazoans. |
| 巻・号 | 23(12) |
| ページ | 568-586 |
| 公開日 | 2022-12-1 |
| DOI | 10.1111/tra.12871 |
| PMID | 36353974 |
| MeSH | Animals Drosophila* Golgi Apparatus / metabolism Larva Salivary Glands / metabolism Secretory Vesicles* / metabolism |
| IF | 4.045 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 8 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 9012R-1 2929R-3 |