論文 - 詳細
| RRC ID | 73097 |
|---|---|
| 著者 | Banreti A, Bhattacharya S, Wien F, Matsuo K, Réfrégiers M, Meinert C, Meierhenrich U, Hudry B, Thompson D, Noselli S. |
| タイトル | Biological effects of the loss of homochirality in a multicellular organism. |
| ジャーナル | Nat Commun |
| Abstract |
Homochirality is a fundamental feature of all known forms of life, maintaining biomolecules (amino-acids, proteins, sugars, nucleic acids) in one specific chiral form. While this condition is central to biology, the mechanisms by which the adverse accumulation of non-L-α-amino-acids in proteins lead to pathophysiological consequences remain poorly understood. To address how heterochirality build-up impacts organism's health, we use chiral-selective in vivo assays to detect protein-bound non-L-α-amino acids (focusing on aspartate) and assess their functional significance in Drosophila. We find that altering the in vivo chiral balance creates a 'heterochirality syndrome' with impaired caspase activity, increased tumour formation, and premature death. Our work shows that preservation of homochirality is a key component of protein function that is essential to maintain homeostasis across the cell, tissue and organ level. |
| 巻・号 | 13(1) |
| ページ | 7059 |
| 公開日 | 2022-11-18 |
| DOI | 10.1038/s41467-022-34516-x |
| PII | 10.1038/s41467-022-34516-x |
| PMID | 36400783 |
| PMC | PMC9674851 |
| MeSH | Amino Acids* / chemistry Proteins* / chemistry Stereoisomerism |
| IF | 12.121 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | CAS-0001 |