| RRC ID |
73097
|
| Author |
Banreti A, Bhattacharya S, Wien F, Matsuo K, Réfrégiers M, Meinert C, Meierhenrich U, Hudry B, Thompson D, Noselli S.
|
| Title |
Biological effects of the loss of homochirality in a multicellular organism.
|
| Journal |
Nat Commun
|
| Abstract |
Homochirality is a fundamental feature of all known forms of life, maintaining biomolecules (amino-acids, proteins, sugars, nucleic acids) in one specific chiral form. While this condition is central to biology, the mechanisms by which the adverse accumulation of non-L-α-amino-acids in proteins lead to pathophysiological consequences remain poorly understood. To address how heterochirality build-up impacts organism's health, we use chiral-selective in vivo assays to detect protein-bound non-L-α-amino acids (focusing on aspartate) and assess their functional significance in Drosophila. We find that altering the in vivo chiral balance creates a 'heterochirality syndrome' with impaired caspase activity, increased tumour formation, and premature death. Our work shows that preservation of homochirality is a key component of protein function that is essential to maintain homeostasis across the cell, tissue and organ level.
|
| Volume |
13(1)
|
| Pages |
7059
|
| Published |
2022-11-18
|
| DOI |
10.1038/s41467-022-34516-x
|
| PII |
10.1038/s41467-022-34516-x
|
| PMID |
36400783
|
| PMC |
PMC9674851
|
| MeSH |
Amino Acids* / chemistry
Proteins* / chemistry
Stereoisomerism
|
| IF |
12.121
|
| Resource |
| Drosophila |
CAS-0001 |
