Reference - Detail
| RRC ID | 73125 |
|---|---|
| Author | Nakagawa K, Nagano T, Katasho R, Iwasaki T, Kamada S. |
| Title | Integrin β1 transduces the signal for LY6D-induced macropinocytosis and mediates senescence-inducing stress-evoked vacuole formation via FAK. |
| Journal | FEBS Lett |
| Abstract |
Cellular senescence is a highly stable cell-cycle arrest induced by DNA damage and various cellular stresses. Recently, we have revealed that lymphocyte antigen 6 complex, locus D (LY6D) is responsible for senescence-inducing stress-evoked vacuole formation through induction of Src family kinase (SFK)-mediated macropinocytosis. However, the signaling molecule(s) transducing the macropinocytosis signal from extracellular LY6D to the cytoplasmic SFK are unknown. In this study, we identified integrin β1, a transmembrane signaling protein, as an interactor of LY6D by proteomic analysis and co-immunoprecipitation assays. Inhibition of integrin β1 impaired LY6D-induced macropinocytosis, and integrin β1 activated SFK through focal adhesion kinase to mediate macropinocytosis. These results indicate that integrin β1 is a crucial mediator of the LY6D-induced vacuole formation in senescent cells. |
| Volume | 596(21) |
| Pages | 2768-2780 |
| Published | 2022-11-1 |
| DOI | 10.1002/1873-3468.14477 |
| PMID | 35999651 |
| MeSH | Focal Adhesion Kinase 1 / genetics Focal Adhesion Kinase 1 / metabolism Focal Adhesion Protein-Tyrosine Kinases / metabolism Integrin beta1* / genetics Integrin beta1* / metabolism Phosphorylation Proteomics* Signal Transduction / physiology Vacuoles / metabolism src-Family Kinases / metabolism |
| IF | 3.057 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | Genome Network Project Human cDNA Clone IRAK026E17 (HGX010513) |