RRC ID 73142
著者 Kobayashi K, Tokuoka M, Sato H, Ariyoshi M, Kawahara S, Fujiwara S, Kishimoto T, Satou Y.
タイトル Regulators specifying cell fate activate cell cycle regulator genes to determine cell numbers in ascidian larval tissues.
ジャーナル Development
Abstract In animal development, most cell types stop dividing before terminal differentiation; thus, cell cycle control is tightly linked to cell differentiation programmes. In ascidian embryos, cell lineages do not vary among individuals, and rounds of the cell cycle are determined according to cell lineages. Notochord and muscle cells stop dividing after eight or nine rounds of cell division depending on their lineages. In the present study, we showed that a Cdk inhibitor, Cdkn1.b, is responsible for stopping cell cycle progression in these lineages. Cdkn1.b is also necessary for epidermal cells to stop dividing. In contrast, mesenchymal and endodermal cells continue to divide even after hatching, and Myc is responsible for maintaining cell cycle progression in these tissues. Expression of Cdkn1.b in notochord and muscle is controlled by transcription factors that specify the developmental fate of notochord and muscle. Likewise, expression of Myc in mesenchyme and endoderm is under control of transcription factors that specify the developmental fate of mesenchyme and endoderm. Thus, cell fate specification and cell cycle control are linked by these transcription factors.
巻・号 149(22)
公開日 2022-11-15
DOI 10.1242/dev.201218
PII 282402
PMID 36278804
MeSH Animals Cell Count Cell Differentiation / genetics Cell Division Genes, Regulator Larva / genetics Notochord Transcription Factors / metabolism Urochordata* / genetics Urochordata* / metabolism
IF 5.611
リソース情報
カタユウレイボヤ・(ニッポンウミシダ) Wild C. int