論文 - 詳細
| RRC ID | 73166 |
|---|---|
| 著者 | Azumi J, Shimada Y, Takeda T, Aso H, Nakamura T. |
| タイトル | The Organogermanium Compound 3-(Trihydroxygermyl) Propanoic Acid (THGP) Suppresses Inflammasome Activation Via Complexation with ATP. |
| ジャーナル | Int J Mol Sci |
| Abstract |
Inflammasome activity is a key indicator of inflammation. The inflammasome is activated by pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs), which activate the p38-NF-κB pathway and promote IL-1β transcription (signaling step 1). Next, extracellular adenosine triphosphate (ATP) activates the inflammasome (a protein complex consisting of a signal recognition protein, an adapter protein, and Caspase-1) and secretion of inflammatory cytokines such as IL-1β (signaling step 2). Inflammasome activation causes excessive inflammation, leading to inflammasome-active diseases such as atherosclerosis and type 2 diabetes. A hydrolysate of the organogermanium compound Ge-132, 3-(Trihydroxygermyl) propanoic acid (THGP) can form a complex with a cis-diol structure. We investigated the inhibitory effect of THGP on inflammasome activity in human THP-1 monocytes. THGP inhibited IL-1β secretion and caspase-1 activation (signaling step 2) in an ATP-dependent manner. On the other hand, THGP did not suppress IL-1β secretion induced by only lipopolysaccharide (LPS) stimulation. In addition, as IL-6 is an ATP-independent inflammatory cytokine, THGP did not decrease its secretion. THGP also suppressed pyroptosis, which is a caspase-1 activity-dependent form of cell death. Therefore, THGP is expected to become a new therapeutic or prophylactic agent for inflammasome-associated diseases. |
| 巻・号 | 23(21) |
| 公開日 | 2022-11-1 |
| DOI | 10.3390/ijms232113364 |
| PII | ijms232113364 |
| PMID | 36362152 |
| PMC | PMC9654755 |
| MeSH | Adenosine Triphosphate / metabolism Caspase 1 / metabolism Cytokines / metabolism Diabetes Mellitus, Type 2* Humans Inflammasomes* / metabolism Inflammation / drug therapy Interleukin-1beta / metabolism Lipopolysaccharides / pharmacology NLR Family, Pyrin Domain-Containing 3 Protein Propionates / pharmacology |
| IF | 4.556 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 18 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | THP-1 RAW 264(RCB0535) |