RRC ID 73320
Author Takagi S, Cocanougher BT, Niki S, Miyamoto D, Kohsaka H, Kazama H, Fetter RD, Truman JW, Zlatic M, Cardona A, Nose A.
Title Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila.
Journal Neuron
Abstract Animals adaptively respond to a tactile stimulus by choosing an ethologically relevant behavior depending on the location of the stimuli. Here, we investigate how somatosensory inputs on different body segments are linked to distinct motor outputs in Drosophila larvae. Larvae escape by backward locomotion when touched on the head, while they crawl forward when touched on the tail. We identify a class of segmentally repeated second-order somatosensory interneurons, that we named Wave, whose activation in anterior and posterior segments elicit backward and forward locomotion, respectively. Anterior and posterior Wave neurons extend their dendrites in opposite directions to receive somatosensory inputs from the head and tail, respectively. Downstream of anterior Wave neurons, we identify premotor circuits including the neuron A03a5, which together with Wave, is necessary for the backward locomotion touch response. Thus, Wave neurons match their receptive field to appropriate motor programs by participating in different circuits in different segments.
Volume 96(6)
Pages 1373-1387.e6
Published 2017-12-20
DOI 10.1016/j.neuron.2017.10.030
PII S0896-6273(17)31022-X
PMID 29198754
MeSH Animals Animals, Genetically Modified Brain / physiology* Brain / ultrastructure Calcium / metabolism Channelrhodopsins / genetics Channelrhodopsins / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster Green Fluorescent Proteins / genetics Green Fluorescent Proteins / metabolism Larva / physiology Locomotion / genetics Locomotion / physiology* Male Microscopy, Electron Neurons / physiology* Neurons / ultrastructure Neurotransmitter Agents / metabolism Optogenetics Physical Stimulation RNA Interference / physiology Touch / physiology* Vesicular Glutamate Transport Proteins / metabolism
IF 14.415
Drosophila DGRC#118824