Reference - Detail
| RRC ID | 73384 |
|---|---|
| Author | Nagafuchi S, Katsuta H, Koyanagi-Katsuta R, Yamasaki S, Inoue Y, Shimoda K, Ikeda Y, Shindo M, Yoshida E, Matsuo T, Ohno Y, Kogawa K, Anzai K, Kurisaki H, Kudoh J, Harada M, Shimizu N. |
| Title | Autoimmune regulator (AIRE) gene is expressed in human activated CD4+ T-cells and regulated by mitogen-activated protein kinase pathway. |
| Journal | Microbiol Immunol |
| Abstract |
The autoimmune regulator (AIRE) gene is a gene responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Here we show that AIRE is expressed in human peripheral CD4-positive T-cells, and most highly in antigen-and interleukin 2-stimulated T (IL-2T) cells. Mitogen-activated protein kinases (MAPKs), including MAPK kinase (MEK) 1/2 and p38 MAPK, were phosphorylated in IL-2T cells and the expression of the AIRE gene was inhibited by a specific p38 MAPK inhibitor (SB203580), thereby indicating that AIRE gene expression is controlled by the MAPK pathway in IL-2T cells. These data suggested the possible significance of the AIRE gene in the peripheral immune system. |
| Volume | 50(12) |
| Pages | 979-87 |
| Published | 2006-1-1 |
| DOI | 10.1111/j.1348-0421.2006.tb03876.x |
| PII | JST.JSTAGE/mandi/50.979 |
| PMID | 17179667 |
| MeSH | CD4-Positive T-Lymphocytes / metabolism* Genes, Regulator Humans MAP Kinase Signaling System / physiology Mitogen-Activated Protein Kinases / antagonists & inhibitors Mitogen-Activated Protein Kinases / metabolism Mitogen-Activated Protein Kinases / physiology* Transcription Factors / genetics Transcription Factors / metabolism* |
| IF | 1.566 |
| Resource | |
| Human and Animal Cells | K562 BALL-1 Daidi TW-EBV-LCL(RCB1438) Jurkat ATN-1(RCB1440) |