Reference - Detail
| RRC ID | 73422 |
|---|---|
| Author | Sakamoto A, Hozumi A, Shiraishi A, Satake H, Horie T, Sasakura Y. |
| Title | The TRP channel PKD2 is involved in sensing the mechanical stimulus of adhesion for initiating metamorphosis in the chordate Ciona. |
| Journal | Dev Growth Differ |
| Abstract |
Metamorphosis is the dramatic and irreversible reconstruction of animal bodies transitioning from the larval stage. Because of the significant impact of metamorphosis on animal life, its timing is strictly regulated. Invertebrate chordate ascidians are the closest living relatives of vertebrates. Ascidians exhibit metamorphosis that converts their swimming larvae into sessile adults. Ascidian metamorphosis is triggered by a mechanical stimulus generated when adhesive papillae adhere to a substrate. However, it is not well understood how the mechanical stimulus is generated and how ascidian larvae sense the stimulus. In this study, we addressed these issues by a combination of embryological, molecular, and genetic experiments in the model ascidian Ciona intestinalis Type A, also called Ciona robusta. We here showed that the epidermal neuronal network starting from the sensory neurons at the adhesive papillae is responsible for the sensing of adhesion. We also found that the transient receptor potential (TRP) channel PKD2 is involved in sensing the stimulus of adhesion. Our results provide a better understanding of the mechanisms underlying the regulation of the timing of ascidian metamorphosis. |
| Volume | 64(7) |
| Pages | 395-408 |
| Published | 2022-9-1 |
| DOI | 10.1111/dgd.12801 |
| PMID | 36053743 |
| MeSH | Animals Ciona* Ciona intestinalis* / genetics Larva Metamorphosis, Biological / physiology Transient Receptor Potential Channels* |
| IF | 1.723 |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 1 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.intestinalis / (O.japonicus) | Wild C.int Tg[MiCiPC2K]2 Tg[MiCiPC2K]3 pSPeGFP pSPCiEpi1H2BmCherry pEF1a>TALEN-NG::2A::mCherry pEF1a>TALEN-HD::2A::mCherry pSP-Kaede |