論文 - 詳細
| RRC ID | 73662 |
|---|---|
| 著者 | Lyu J, Kubo T, Iwahashi S, Fukasawa K, Horie T, Nagamatsu K, Ikeno K, Nakamura G, Kamakura M, Hinoi E. |
| タイトル | Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly. |
| ジャーナル | Biol Pharm Bull |
| Abstract |
Royal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revealed that raw RJ significantly reduced the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix (ECM). Similar results were observed after treatment with 10-hydroxy-2-decenoic acid, the most abundant and unique fatty acid in raw RJ. Our results suggest that oral supplementation with RJ would benefit the maintenance of joint health and prophylaxis against OA, possibly by suppressing the activity of inflammatory cytokines and ECM-degrading enzymes. |
| 巻・号 | 46(2) |
| ページ | 348-353 |
| 公開日 | 2023-1-1 |
| DOI | 10.1248/bpb.b22-00654 |
| PMID | 36724964 |
| MeSH | Animals Bees Cytokines / metabolism Dietary Supplements Fatty Acids* / pharmacology Fatty Acids* / therapeutic use Mice Osteoarthritis* / drug therapy Osteoarthritis* / prevention & control |
| IF | 1.863 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 13 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | ATDC5(RCB0565) |