RRC ID 73662
著者 Lyu J, Kubo T, Iwahashi S, Fukasawa K, Horie T, Nagamatsu K, Ikeno K, Nakamura G, Kamakura M, Hinoi E.
タイトル Amelioration of Osteoarthritis Development by Daily Oral Supplementation of Royal Jelly.
ジャーナル Biol Pharm Bull
Abstract Royal jelly (RJ), an essential food for the queen honeybee, has a variety of biological activities. Although RJ exerts preventive effects on various lifestyle-related diseases, such as osteoporosis and obesity, no study evaluated the effect of RJ on the development of osteoarthritis (OA), the most common degenerative joint disease. Here, we showed that daily oral administration of raw RJ significantly prevented OA development in vivo following surgically-induced knee joint instability in mice. Furthermore, in vitro experiments using chondrocytes, revealed that raw RJ significantly reduced the expression of inflammatory cytokines and enzymes critical for the degradation of the extracellular matrix (ECM). Similar results were observed after treatment with 10-hydroxy-2-decenoic acid, the most abundant and unique fatty acid in raw RJ. Our results suggest that oral supplementation with RJ would benefit the maintenance of joint health and prophylaxis against OA, possibly by suppressing the activity of inflammatory cytokines and ECM-degrading enzymes.
巻・号 46(2)
ページ 348-353
公開日 2023-1-1
DOI 10.1248/bpb.b22-00654
PMID 36724964
MeSH Animals Bees Cytokines / metabolism Dietary Supplements Fatty Acids* / pharmacology Fatty Acids* / therapeutic use Mice Osteoarthritis* / drug therapy Osteoarthritis* / prevention & control
IF 1.863
リソース情報
ヒト・動物細胞 ATDC5(RCB0565)