Reference - Detail
| RRC ID | 73664 |
|---|---|
| Author | Michael Nicosia, Juyeun Lee, Ashley Beavers, Danielle Kish, George W Farr, Paul R McGuirk, Marc F Pelletier, Justin D Lathia, Robert L Fairchild, Anna Valujskikh |
| Title | Water channel Aquaporin 4 is required for T cell receptor mediated lymphocyte activation |
| Journal | Journal of Leukocyte Biology |
| Abstract |
Aquaporins are a family of ubiquitously expressed transmembrane water channels implicated in a broad range of physiological functions. We have previously reported that Aquaporin 4 (AQP4) is expressed on T cells and that treatment with a small molecule AQP4 inhibitor significantly delays T cell mediated heart allograft rejection. Using either genetic deletion or small molecule inhibitor, we show that AQP4 supports T cell receptor mediated activation of both mouse and human T cells. Intact AQP4 is required for optimal T cell receptor (TCR) related signaling events, including nuclear translocation of transcription factors and phosphorylation of proximal TCR signaling molecules. AQP4 deficiency or inhibition impairs actin cytoskeleton rearrangements following TCR cross-linking, causing inferior TCR polarization and a loss of TCR signaling. Our findings reveal a novel function of AQP4 in T lymphocytes and identify AQP4 as a potential therapeutic target for preventing TCR-mediated T cell activation. |
| Published | 2023-2-1 |
| DOI | 10.1093/jleuko/qiad010 |
| PMID | 36805947 |
| IF | 3.757 |
| Resource | |
| Mice | RBRC04364 |