RRC ID 73723
Author Takiguchi Y, Miyamoto T, Nagao K, Kuriyama T.
Title Assessment of the homogeneous efficacy of carbon ions in the spread-out Bragg peak for human lung cancer cell lines.
Journal Radiat Med
Abstract PURPOSE:The aim of this study was to assess the radiosensitivities and homogeneous efficacy in the spread-out Bragg peak (SOBP) for lung cancer cell lines exposed to carbon ions.
MATERIALS AND METHODS:The dose-dependent survival rates of seven cell lines exposed to carbon ions, fast neutrons, and photons were obtained using colony-forming assays in vitro. The relative biological effectiveness (RBE) of carbon ions and fast neutrons to photons was determined by comparing the doses at the 10% and 1% survival levels.
RESULTS:The RBEs at 13, 40, 50, and 80 keV/microm were 1.20-1.29, 1.55-1.80, 1.57-2.00, and 1.69-2.58, respectively, at the 10% survival level. The RBE of 290 MeV carbon ions increased with increasing linear energy transfer. The biological dose (relative physical dose x RBE) distributions in the SOBP did not statistically differ at the proximal, mid, or distal points at the 10% (p = 0.945) and 1% (p = 0.211) survival levels, respectively; however, deviation of the biological dose at 10% and 1% survival were 3%-16% and 6%-24%, respectively. Furthermore, 290 MeV carbon ions at 80 keV/microm in the SOBP were nearly equivalent to 30 MeV fast neutrons.
CONCLUSION:Our results demonstrate nearly homogeneous effectiveness in the SOBP, although we are aware of the deviation in some cell lines.
Volume 25(6)
Pages 272-7
Published 2007-7-1
DOI 10.1007/s11604-007-0134-6
PMID 17634880
MeSH Carbon / pharmacology* Cell Line, Tumor / radiation effects* Cell Survival Dose-Response Relationship, Radiation Humans Lung Neoplasms / pathology* Radiation Tolerance Stem Cells
Human and Animal Cells HLC-1(RCB0083) LC-2/ad(RCB0440) RERF-LC-AI(RCB0444)