論文 - 詳細
| RRC ID | 73739 |
|---|---|
| 著者 | Tanaka Y, Furuhata E, Maeda S, Kishima M, Suzuki H, Suzuki T. |
| タイトル | A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells. |
| ジャーナル | Sci Data |
| Abstract |
Hepatocytes are a major parenchymal cell type in the liver and play an essential role in liver function. Hepatocyte-like cells can be differentiated in vitro from induced pluripotent stem cells (iPSCs) via definitive endoderm (DE)-like cells and hepatoblast-like cells. Here, we explored the in vitro differentiation time-course of hepatocyte-like cells. We performed methylome and transcriptome analyses for hepatocyte-like cell differentiation. We also analyzed DE-like cell differentiation by methylome, transcriptome, chromatin accessibility, and GATA6 binding profiles, using finer time-course samples. In this manuscript, we provide a detailed description of the dataset and the technical validations. Our data may be valuable for the analysis of the molecular mechanisms underlying hepatocyte and DE differentiations. |
| 巻・号 | 10(1) |
| ページ | 93 |
| 公開日 | 2023-2-14 |
| DOI | 10.1038/s41597-023-02001-9 |
| PII | 10.1038/s41597-023-02001-9 |
| PMID | 36788249 |
| PMC | PMC9929325 |
| MeSH | Cell Differentiation* Endoderm Hepatocytes Humans Induced Pluripotent Stem Cells* Liver |
| IF | 5.541 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 201B7(HPS0063) |