論文 - 詳細
| RRC ID | 73905 |
|---|---|
| 著者 | Oda AH, Tamura M, Kaneko K, Ohta K, Hatakeyama TS. |
| タイトル | Autotoxin-mediated latecomer killing in yeast communities. |
| ジャーナル | PLoS Biol |
| Abstract |
Cellular adaptation to stressful environments such as starvation is essential to the survival of microbial communities, but the uniform response of the cell community may lead to entire cell death or severe damage to their fitness. Here, we demonstrate an elaborate response of the yeast community against glucose depletion, in which the first adapted cells kill the latecomer cells. During glucose depletion, yeast cells release autotoxins, such as leucic acid and L-2keto-3methylvalerate, which can even kill the clonal cells of the ones producing them. Although these autotoxins were likely to induce mass suicide, some cells differentiated to adapt to the autotoxins without genetic changes. If nondifferentiated latecomers tried to invade the habitat, autotoxins damaged or killed the latecomers, but the differentiated cells could selectively survive. Phylogenetically distant fission and budding yeast shared this behavior using the same autotoxins, suggesting that latecomer killing may be the universal system of intercellular communication, which may be relevant to the evolutional transition from unicellular to multicellular organisms. |
| 巻・号 | 20(11) |
| ページ | e3001844 |
| 公開日 | 2022-11-1 |
| DOI | 10.1371/journal.pbio.3001844 |
| PII | PBIOLOGY-D-22-00582 |
| PMID | 36342925 |
| PMC | PMC9639812 |
| MeSH | Cell Death Germ Cells Glucose Humans Saccharomyces cerevisiae* / genetics Yeast, Dried* |
| IF | 7.076 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 48 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 酵母 | FY7755 |