論文 - 詳細
| RRC ID | 74074 |
|---|---|
| 著者 | Suenaga T, Mori Y, Suzutani T, Arase H. |
| タイトル | Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. |
| ジャーナル | Biochem Biophys Res Commun |
| Abstract |
Sialic acid immunoglobulin-like lectin (Siglec) family molecules are immune regulatory receptors that bind to specific molecules containing sialic acids. Varicella-zoster virus (VZV), a member of the herpesvirus family, infects hematopoietic cells and spreads throughout the body, causing chickenpox, shingles, and, sometimes fatal encephalomyelitis. However, the cellular entry receptors that are required for VZV to infect hematopoietic cells have remained unclear. Here, we found that Siglec-7, mainly expressed on hematopoietic cells, binds to VZV envelope glycoprotein B in a sialic acid-dependent manner. Furthermore, Siglec-7 mediated VZV infection by inducing membrane fusion. Our findings provide the first evidence for a molecular mechanism by which VZV infects hematopoietic cells. |
| 巻・号 | 607 |
| ページ | 67-72 |
| 公開日 | 2022-6-4 |
| DOI | 10.1016/j.bbrc.2022.03.060 |
| PII | S0006-291X(22)00391-6 |
| PMID | 35367830 |
| MeSH | Antigens, Differentiation, Myelomonocytic* / metabolism Chickenpox* Herpes Zoster* Herpesvirus 3, Human Humans Lectins* / metabolism N-Acetylneuraminic Acid Sialic Acid Binding Immunoglobulin-like Lectins Viral Envelope Proteins |
| IF | 2.985 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | 293T(RCB2202) |