論文 - 詳細
| RRC ID | 74098 |
|---|---|
| 著者 | Nishida K, Nishimura SN, Tanaka M. |
| タイトル | Selective Accumulation to Tumor Cells with Coacervate Droplets Formed from a Water-Insoluble Acrylate Polymer. |
| ジャーナル | Biomacromolecules |
| Abstract |
Selective targeting of specific cells without the use of biological ligands has not been achieved. In the present study, we revealed that the coacervate droplets formed from poly(2-methoxyethyl acrylate) (PMEA) and its derivatives selectively accumulated to tumor cells. PMEA derivatives, which are insoluble acrylate polymers, induced coacervation in water to form polymer-dense droplets via hydrophobic interaction. Interestingly, the accumulation of coacervate droplets to tumor cells was involved in the bound water content of PMEA derivatives. Coacervate droplets with a high bound water content accumulated and internalized up to 36.6-fold higher in HeLa cervical tumor cells than in normal human fibroblasts (NHDF). Moreover, the interactions between coacervate droplets and plasma membrane components such as CD44 played a key role in this accumulation process. Therefore, coacervate droplets formed from PMEA derivatives have great clinical potential in tumor cell detection, development of alternative tumor-targeting ligands, and optimization of drug delivery carriers. |
| 巻・号 | 23(4) |
| ページ | 1569-1580 |
| 公開日 | 2022-4-11 |
| DOI | 10.1021/acs.biomac.1c01343 |
| PMID | 35089709 |
| MeSH | Acrylates Biocompatible Materials / chemistry Humans Ligands Polymers* / chemistry Water* / chemistry |
| IF | 6.092 |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ヒト・動物細胞 | HeLa |